BACITRACIN USP CONTAINS A FACTOR THAT STIMULATES RECEPTORS FOR 5-HYDROXYTRYPTAMINE ON RABBIT AORTIC STRIPS

被引：2

作者：

DEBLOIS, D ^{[1
]}

BOUTHILLIER, J ^{[1
]}

MARCEAU, F ^{[1
]}

机构：

[1] UNIV LAVAL,FAC MED,DEPT PHARMACOL,CITE UNIV,QUEBEC CITY G1K 7P4,QUEBEC,CANADA

来源：

LIFE SCIENCES | 1990年 / 47卷 / 19期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(90)90355-U

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bactracin (BAC) U.S.P., obtained in the form of sterile powder, elicits dose-dependent and non-tachyphylactic contractions of the rabbit isolated aorta and of other rabbit vessels. The use of several pharmacologic antagonists suggests that BAC is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is competitively antagonized by methysergide and ketanserin with pA2 values compatible with an agonist action on the 5-HT2 receptors found in the aortic preparation. It remains to be determined whether bacitracin A, the chief constituent of BAC U.S.P., is the 5-HT agonist. © 1990.

引用

页码：PL103 / PL108

页数：6

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