PICROTOXIN-INDUCED TONIC-CLONIC SEIZURES AND LETHALITY ARE DECREASED BY MK-801 IN DEVELOPING RATS

被引：19

作者：

VELISKOVA, J

VELISEK, LS

机构：

[1] CHARLES UNIV, FAC MED 3, DEPT PHYSIOL & CLIN PHYSIOL, CS-11636 PRAGUE 1, CZECHOSLOVAKIA

[2] CZECHOSLOVAK ACAD SCI, INST PHYSIOL, CS-11142 PRAGUE 1, CZECHOSLOVAKIA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1992年 / 43卷 / 01期

关键词：

SEIZURE; NEURAL DEVELOPMENT; PICROTOXIN; MK-801;

D O I：

10.1016/0091-3057(92)90670-B

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The action of MK-801 (NMDA antagonist; 0.1 and 0.5 mg/kg, IP) was tested against picrotoxin-induced seizures (3-6 mg/kg, IP) in rats aged 7, 12, 18, 25, and 90 days. We found MK-801 only inconsistently affected clonic seizures in 12- and 25-day-old rats, whereas tonic-clonic seizures were suppressed or delayed in almost all age groups. In addition, the lethality of picrotoxin was diminished by the higher dose of MK-801 in all age groups. The results suggest: a) different generators for both seizure patterns (clonic and tonic-clonic), b) an involvement of NMDA receptors in the genesis of tonic-clonic seizure pattern, and c) an interaction of MK-801 with GABAergic transmission throughout the entire development studied.

引用

页码：291 / 295

页数：5

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