A PILOT-STUDY OF PHOTODYNAMIC THERAPY IN PATIENTS WITH INOPERABLE NON-SMALL-CELL LUNG-CANCER

被引：36

作者：

SUTEDJA, T ^{[1
]}

BAAS, P ^{[1
]}

STEWART, F ^{[1
]}

VANZANDWIJK, N ^{[1
]}

机构：

[1] NETHERLANDS CANC INST,ANTONI VAN LEEUWENHOEKHUIS,DIV EXPTL THERAPY,1066 CX AMSTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CANCER | 1992年 / 28A卷 / 8-9期

关键词：

D O I：

10.1016/0959-8049(92)90522-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

26 patients with inoperable non-small cell lung cancer (NSCLC) were treated with photodynamic therapy (PDT) with intravenous Photofrin II 2 mg/kg. 10 out of 11 stage I patients achieved a complete response. The remaining patient, and 11 out of 15 stage III patients had a partial response. No response was seen in 4 patients, 2 of whom had inadequate illumination. Thus, the objective response rate was 85% (22/26). Although lung function did not improve, dyspnoea was ameliorated in 7 (58%) of the partial responders. 4 stage III patients had tumour progression and died of pulmonary haemorrhages 1.5-6 months after PDT. All had received external irradiation, Nd-YAG laser and/or brachytherapy before PDT. 4 patients had grade I-II skin photosensitivity. Although of value in stage I NSCLC, the clinical benefit of PDT in stage III disease was small.

引用

页码：1370 / 1373

页数：4

共 17 条

[1] PHOTODYNAMIC THERAPY - ACHIEVEMENTS AND PROSPECTS [J].

ASH, D ;

BROWN, SB .

BRITISH JOURNAL OF CANCER, 1989, 60 (02) :151-152

[2]

BALCHUM OJ, 1985, CLIN CHEST MED, V6, P255

[3] PHOTODYNAMIC THERAPY - NEW APPROACHES [J].

DOUGHERTY, TJ .

SEMINARS IN SURGICAL ONCOLOGY, 1989, 5 (01) :6-16

[4] CUTANEOUS PHOTOTOXIC OCCURRENCES IN PATIENTS RECEIVING PHOTOFRIN [J].

DOUGHERTY, TJ ;

COOPER, MT ;

MANG, TS .

LASERS IN SURGERY AND MEDICINE, 1990, 10 (05) :485-488

[5] PROPERTIES AND APPLICATIONS OF PHOTODYNAMIC THERAPY [J].

GOMER, CJ ;

RUCKER, N ;

FERRARIO, A ;

WONG, S .

RADIATION RESEARCH, 1989, 120 (01) :1-18

[6]

HAYATA Y, 1989, LUNG CANCER ADV CONC, P77

[7] ENDOSCOPIC PALLIATION OF TRACHEOBRONCHIAL MALIGNANCIES [J].

HETZEL, MR ;

SMITH, SGT .

THORAX, 1991, 46 (05) :325-333

[8]

HORAI T, 1989, Lasers in Medical Science, V4, P1, DOI 10.1007/BF02032502

[9]

KONAKA C, 1987, Lasers in Medical Science, V2, P17, DOI 10.1007/BF02594125

[10] A RANDOMIZED COMPARATIVE-STUDY OF THE SAFETY AND EFFICACY OF PHOTODYNAMIC THERAPY USING PHOTOFRIN-II COMBINED WITH PALLIATIVE RADIOTHERAPY VERSUS PALLIATIVE RADIOTHERAPY ALONE IN PATIENTS WITH INOPERABLE OBSTRUCTIVE NON-SMALL CELL BRONCHOGENIC-CARCINOMA [J].

LAM, S ;

KOSTASHUK, EC ;

COY, EP ;

LAUKKANEN, E ;

LERICHE, JC ;

MUELLER, HA ;

SZASZ, IJ .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (05) :893-897

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