HIGH-DOSE RAPID SCHEDULE CHEMOTHERAPY FOR DISSEMINATED NEUROBLASTOMA

被引:42
作者
PEARSON, ADJ
CRAFT, AW
PINKERTON, CR
MELLER, ST
REID, MM
机构
[1] ROYAL MARSDEN HOSP,DEPT PAEDIAT ONCOL,SUTTON,SURREY,ENGLAND
[2] ROYAL VICTORIA INFIRM,DEPT CHILD HLTH,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[3] ROYAL VICTORIA INFIRM,DEPT HAEMATOL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
关键词
D O I
10.1016/0959-8049(92)90062-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In a high-dose schedule for disseminated neuroblastoma, eight courses of chemotherapy were administered every 10 days, regardless of myelosuppression, to eradicate tumour cells rapidly and reduce emergence of drug-resistant clones. Relatively non-myelotoxic vincristine and cisplatin were alternated with high-dose cisplatin-etoposide and cyclophosphamide-etoposide. Of 12 evaluable patients, there were 1 complete (CR), 3 very good partial (VGPR), 5 partial (PR) and 3 mixed responses (MR) 100 days after starting treatment. 6 out of 9 achieved a bone marrow CR at 40 days. 9 of 11 primary tumours were completely resected, after which 4 patients had CR, 3 VGPR (bone scan alone being abnormal), 4 PR and 1 mixed response (MR). Myelotoxicity was the major adverse effect. The only death was due to fungal infection. Clinically important renal dysfunction occurred in 3 patients. 4 had convulsions and 4 temporary hypertension. This schedule produced a rapid response and its toxicity, though serious, was manageable. Further evaluation is warranted.
引用
收藏
页码:1654 / 1659
页数:6
相关论文
共 34 条
[1]  
ARMSTRON.JG, 1968, CANCER CHEMOTH REP, V52, P527
[2]  
BAUM ES, 1981, CANCER TREAT REP, V65, P815
[3]   INCREASED PLASMA-RENIN AND ALDOSTERONE IN PATIENTS TREATED WITH CISPLATIN-BASED CHEMOTHERAPY FOR METASTATIC GERM-CELL TUMORS [J].
BOSL, GJ ;
LEITNER, SP ;
ATLAS, SA ;
SEALEY, JE ;
PREIBISZ, JJ ;
SCHEINER, E .
JOURNAL OF CLINICAL ONCOLOGY, 1986, 4 (11) :1684-1689
[4]   CISPLATIN OTOTOXICITY IN CHILDREN - A PRACTICAL GRADING SYSTEM [J].
BROCK, PR ;
BELLMAN, SC ;
YEOMANS, EC ;
PINKERTON, CR ;
PRITCHARD, J .
MEDICAL AND PEDIATRIC ONCOLOGY, 1991, 19 (04) :295-300
[5]   INTERNATIONAL CRITERIA FOR DIAGNOSIS, STAGING, AND RESPONSE TO TREATMENT IN PATIENTS WITH NEURO-BLASTOMA [J].
BRODEUR, GM ;
SEEGER, RC ;
BARRETT, A ;
BERTHOLD, F ;
CASTLEBERRY, RP ;
DANGIO, G ;
DEBERNARDI, B ;
EVANS, AE ;
FAVROT, M ;
FREEMAN, AI ;
HAASE, G ;
HARTMANN, O ;
HAYES, FA ;
HELSON, L ;
KEMSHEAD, J ;
LAMPERT, F ;
NINANE, J ;
OHKAWA, H ;
PHILIP, T ;
PINKERTON, CR ;
PRITCHARD, J ;
SAWADA, T ;
SIEGEL, S ;
SMITH, EI ;
TSUCHIDA, Y ;
VOUTE, PA .
JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (12) :1874-1881
[6]   COINDUCTION OF MDR-1 MULTIDRUG-RESISTANCE AND CYTOCHROME-P-450 GENES IN RAT-LIVER BY XENOBIOTICS [J].
BURT, RK ;
THORGEIRSSON, SS .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1988, 80 (17) :1383-1386
[7]   A DOSE AND TIME RESPONSE ANALYSIS OF THE TREATMENT OF HODGKINS-DISEASE WITH MOPP CHEMOTHERAPY [J].
CARDE, P ;
MACKINTOSH, FR ;
ROSENBERG, SA .
JOURNAL OF CLINICAL ONCOLOGY, 1983, 1 (02) :146-153
[8]   IMMUNOCYTOCHEMICAL EXAMINATION OF BONE-MARROW IN DISSEMINATED NEUROBLASTOMA [J].
CAREY, PJ ;
THOMAS, L ;
BUCKLE, G ;
REID, MM .
JOURNAL OF CLINICAL PATHOLOGY, 1990, 43 (01) :9-12
[9]   CHEMOTHERAPY DOSE INTENSITY CORRELATES STRONGLY WITH RESPONSE, MEDIAN SURVIVAL, AND MEDIAN PROGRESSION-FREE SURVIVAL IN METASTATIC NEUROBLASTOMA [J].
CHEUNG, NKV ;
HELLER, G .
JOURNAL OF CLINICAL ONCOLOGY, 1991, 9 (06) :1050-1058
[10]   DOSE - A CRITICAL FACTOR IN CANCER-CHEMOTHERAPY [J].
FREI, E ;
CANELLOS, GP .
AMERICAN JOURNAL OF MEDICINE, 1980, 69 (04) :585-594