PLASMA GLUTAMINE CONCENTRATION - A GUIDE IN THE MANAGEMENT OF UREA CYCLE DISORDERS

被引：46

作者：

MAESTRI, NE ^{[1
]}

MCGOWAN, KD ^{[1
]}

BRUSILOW, SW ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH MED,DEPT PEDIAT,600 N WOLFE ST, PK BLDG ROOM 336, BALTIMORE, MD 21205 USA

来源：

JOURNAL OF PEDIATRICS | 1992年 / 121卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(05)81200-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Because increases in plasma glutamine concentrations are almost always associated with hyperammonemia in patients with urea cycle disorders, we determined the correlation between these two variables for 2 years in a child with ornithine transcarbamylase deficiency. A correlation coefficient of 0.77 (p<0.0001) was found. Hyperammonemia was rarely observed when plasma glutamine levels were near normal. These data suggest that one goal of therapy is the maintenance of plasma glutamine levels at or near normal values.

引用

页码：259 / 261

页数：3

共 14 条

[1]

ANSLEY JD, 1978, GASTROENTEROLOGY, V75, P570

[2] HYPERAMMONEMIA IN WOMEN WITH A MUTATION AT THE ORNITHINE CARBAMOYLTRANSFERASE LOCUS - A CAUSE OF POSTPARTUM COMA [J].