GROWTH-FACTORS AND VITAMIN-E MODIFY NEURONAL GLUTAMATE TOXICITY

被引:164
作者
SCHUBERT, D [1 ]
KIMURA, H [1 ]
MAHER, P [1 ]
机构
[1] WHITTIER INST,LA JOLLA,CA 92037
关键词
D O I
10.1073/pnas.89.17.8264
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The sympathetic nerve cell line PC-12 is killed by glutamate in a concentration-dependent manner. Although glycine and the deletion of magnesium weakly potentiate glutamate toxicity and PC-12 cells express N-methyl-D-aspartate-receptor mRNA, most toxicity is mediated by means of a mechanism independent of typical N-methyl-D-aspartate receptors. Glutamate toxicity is, however, greatly enhanced by prior exposure to nerve growth factor or basic fibroblast growth factor. Glutamate killing is blocked by epidermal growth factor and, to a lesser extent, by vitamin E. These observations show that synergistic interactions between growth factors and excitotoxic amino acids may play critical roles in the developing nervous system and that antioxidants attenuate this toxicity.
引用
收藏
页码:8264 / 8267
页数:4
相关论文
共 28 条
[1]   ESTABLISHMENT OF FUNCTIONAL CLONAL LINES OF NEURONS FROM MOUSE NEUROBLASTOMA [J].
AUGUSTIT.G ;
SATO, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 64 (01) :311-&
[2]  
BAIRD A, 1990, PEPTIDE GROWTH FACTO, P197
[3]   GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].
CHOI, DW .
NEURON, 1988, 1 (08) :623-634
[4]   N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST DESEGREGATES EYE-SPECIFIC STRIPES [J].
CLINE, HT ;
DEBSKI, EA ;
CONSTANTINEPATON, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) :4342-4345
[5]   MECHANISM OF KAINATE TOXICITY TO CEREBELLAR NEURONS INVITRO IS ANALOGOUS TO REPERFUSION TISSUE-INJURY [J].
DYKENS, JA ;
STERN, A ;
TRENKNER, E .
JOURNAL OF NEUROCHEMISTRY, 1987, 49 (04) :1222-1228
[6]   APPLICATIONS OF QUANTITATIVE MEASUREMENTS FOR ASSESSING GLUTAMATE NEUROTOXICITY [J].
FINKBEINER, S ;
STEVENS, CF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (11) :4071-4074
[7]   CHARACTERIZATION AND MECHANISM OF GLUTAMATE NEUROTOXICITY IN PRIMARY STRIATAL CULTURES [J].
FREESE, A ;
DIFIGLIA, M ;
KOROSHETZ, WJ ;
BEAL, MF ;
MARTIN, JB .
BRAIN RESEARCH, 1990, 521 (1-2) :254-264
[8]   MOLECULAR NEUROBIOLOGY OF GLUTAMATE RECEPTORS [J].
GASIC, GP ;
HOLLMANN, M .
ANNUAL REVIEW OF PHYSIOLOGY, 1992, 54 :507-536
[9]   PROPERTIES OF 2 TEMPERATURE-SENSITIVE ROUS-SARCOMA VIRUS-TRANSFORMED CEREBELLAR CELL-LINES [J].
GIOTTA, GJ ;
HEITZMANN, J ;
COHN, M .
BRAIN RESEARCH, 1980, 202 (02) :445-458
[10]   ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR [J].
GREENE, LA ;
TISCHLER, AS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) :2424-2428