INTERACTIONS OF GINSENOSIDES WITH LIGAND-BINDINGS OF GABA(A) AND GABA(B) RECEPTORS

被引：77

作者：

KIMURA, T

SAUNDERS, PA

KIM, HS

RHEU, HM

OH, KW

HO, IK

机构：

[1] UNIV MISSISSIPPI,MED CTR,DEPT PHARMACOL & TOXICOL,JACKSON,MS 39216

[2] CHUNGBUK NATL UNIV,COLL PHARM,DEPT PHARMACOL,CHONGJU 360763,SOUTH KOREA

来源：

GENERAL PHARMACOLOGY | 1994年 / 25卷 / 01期

关键词：

D O I：

10.1016/0306-3623(94)90032-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Total saponin fraction decreased the affinity of specific [H-3]muscimol binding without changes in B-max. Ginsenoside Rb-1 Rb-2, Rc, Re, Rf and Rg, inhibited the specific [H-3]muscimol binding to the high-affinity site. 2. Total saponin fraction increased the affinity of specific [H-3]flunitrazepam binding. Ginsenoside Re and Rf enhanced specific [H-3]flunitrazepam binding. 3. Total saponin fraction decreased the affinity of specific [S-35]TBPS binding without changes in B-max. Ginsenosides did not affect specific or non-specific [S-35]TBPS binding. 4. Total saponin fraction decreased the affinity of specific [H-3]baclofen binding without changes in B-max. Ginsenoside Rc inhibited specific [H-3]baclofen binding.

引用

页码：193 / 199

页数：7

共 33 条

[1] A-G PROTEIN COUPLES SEROTONIN AND GABA-B RECEPTORS TO THE SAME CHANNELS IN HIPPOCAMPUS [J].