EFFECTS OF AN A1 ADENOSINE RECEPTOR AGONIST ON THE NEUROCHEMICAL, BEHAVIORAL AND HISTOLOGICAL CONSEQUENCES OF ISCHEMIA

被引:53
作者
HERON, A [1 ]
LEKIEFFRE, D [1 ]
LEPEILLET, E [1 ]
LASBENNES, F [1 ]
SEYLAZ, J [1 ]
PLOTKINE, M [1 ]
BOULU, RG [1 ]
机构
[1] UNIV PARIS 05, UFR PHARM, PHARMACOL LAB, F-75270 PARIS 06, FRANCE
关键词
FOREBRAIN ISCHEMIA; R-PHENYLISOPROPYLADENOSINE; AMINO ACID RELEASE; MICRODIALYSIS; BEHAVIOR; NEURONAL DAMAGE; RAT;
D O I
10.1016/0006-8993(94)90149-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Untreated rats and rats given the Al receptor adenosine agonist, R-phenylisopropyladenosine (R-PIA), were subjected to four vessel ischemia. The effect of R-PIA on hippocampal amino acid release, hippocampal neuronal damage, exploratory behavior, learning capacity and global neurological score were evaluated. R-PIA decreased by half the glutamate released during ischemia and improved the global neurological scores 3, 24, 48, 78 h and 7 days after ischemia. But R-PIA had no effect on taurine/GABA release (during ischemia), hippocampal neuronal damage (7 days post-ischemia), exploratory behavior (48 h post-ischemia) or learning capacity (7 days post-ischemia). Thus, a decrease in glutamate release by R-PIA is not systematically correlated with an improvement of histological damage or learning capacity. Reduced glutamate release is not therefore a sufficient criterion on which to evaluate the neuroprotective capacity of a drug.
引用
收藏
页码:217 / 224
页数:8
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