PHENYLSELENYLATION OF ARACHIDONIC-ACID AS A ROUTE TO INTERMEDIATES FOR LEUKOTRIENE SYNTHESIS - ISOMERIZATION OF CONJUGATED DIENES DURING SELENOXIDE ELIMINATION

被引：12

作者：

BALDWIN, JE

REED, NV

THOMAS, EJ

机构：

来源：

TETRAHEDRON | 1981年 / 37卷

关键词：

D O I：

10.1016/0040-4020(81)85063-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl (5SR, 6SR)-5-hydroxy-6-phenylselenyleicosa-cis,cis,cis-8,11,14-trienoate, available in 2 steps from arachidonic acid, undergoes oxidative deselenylation to give selectively either methyl (5SR)-5-hydroxyeicosa-trans,trans,cis,cis-6,8,11,14-tetraenoate or its cis-8 isomer, depending upon the reaction conditions. [Leukotrienes are implicated in the biosynthesis of slow-reacting substances, important agonists in hypersensitivity.].

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页码：263 / 267

页数：5

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