INHIBITORY EFFECT OF TOPICAL APPLICATION OF POLYMERIZED FERULIC ACID, A SYNTHETIC LIGNIN, ON TUMOR PROMOTION IN MOUSE SKIN 2-STAGE TUMORIGENESIS

被引：23

作者：

ASANOMA, M

TAKAHASHI, K

MIYABE, M

YAMAMOTO, K

YOSHIMI, N

MORI, H

KAWAZOE, Y

机构：

[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

[2] NAGOYA CITY PUBL HLTH RES INST,MIZUHO KU,NAGOYA,AICHI 467,JAPAN

[3] GIFU UNIV,SCH MED,DEPT PATHOL,GIFU 500,JAPAN

来源：

CARCINOGENESIS | 1994年 / 15卷 / 09期

关键词：

D O I：

10.1093/carcin/15.9.2069

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A dehydrogenation polymer of ferulic acid (DHP-FA), a synthetic lignin, was evaluated for its ability to inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the 7,12-dimethylbenz[a]anthracene-treated skin of female ICR mice. Topical application of DHP-FA inhibits TPA-induced tumor promotion, whereas a monomeric ferulic acid does not show the inhibitory effect.

引用

页码：2069 / 2071

页数：3

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