MONITORING OCCUPATIONAL EXPOSURE TO STYRENE FROM HEMOGLOBIN ADDUCTS AND METABOLITES IN BLOOD

被引:51
作者
CHRISTAKOPOULOS, A
BERGMARK, E
ZORCEC, V
NORPPA, H
MAKIPAAKKANEN, J
OSTERMANGOLKAR, S
机构
[1] UNIV STOCKHOLM,ARRHENIUS LABS NAT SCI,DEPT RADIOBIOL,S-10691 STOCKHOLM,SWEDEN
[2] INST OCCUPAT HLTH,DEPT IND HYG & TOXICOL,SF-00290 HELSINKI 29,FINLAND
关键词
GAS-CHROMATOGRAPHY MASS-SPECTROMETRY; N-ALKYL EDMAN PROCEDURE; STYRENE GLYCOL IN BLOOD; STYRENE 7,8-OXIDE IN BLOOD; URINARY MANDELIC ACID;
D O I
10.5271/sjweh.1476
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Monitoring occupational exposure to styrene was achieved through quantification of adducts of styrene 7,8-oxide to N-terminal valine in hemoglobin (Hb) on the basis of the enrichment of adducted globin chains by ion-exchange chromatography and gas chromatographic-mass spectrometric analysis by the use of the N-alkyl Edman method. Application to blood samples from reinforced plastics workers exposed to styrene and from referents showed Hb adduct levels correlating with the blood styrene glycol and urinary mandelic acid concentrations. The blood styrene glycol and styrene 7,8-oxide levels of the exposed workers averaged 2.5 mumol . l-1 (17 subjects) and 0.09 mumol . l-1 (7 subjects), respectively. The blood styrene glycol and urinary mandelic acid content (mean 9.5 mmol . l-1, 17 subjects) suggested a styrene concentration of about 300 mg . m-3 (75 ppm) in the workplace air. The Hb adduct levels were low (mean 28 pmol . g-1), indicating rapid detoxification of styrene 7,8-oxide in humans.
引用
收藏
页码:255 / 263
页数:9
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