EFFECT OF IL-2 ON IMMUNOGLOBULIN PRODUCTION BY ANTI-CD40-ACTIVATED HUMAN B-CELLS - SYNERGISTIC EFFECT WITH IL-10 AND ANTAGONISTIC EFFECT WITH IL-4

被引:26
作者
NONOYAMA, S [1 ]
FARRINGTON, ML [1 ]
OCHS, HD [1 ]
机构
[1] UNIV WASHINGTON,DEPT PEDIAT,SEATTLE,WA 98195
来源
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1994年 / 72卷 / 03期
关键词
D O I
10.1006/clin.1994.1155
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Activation of B cells by anti-CD40 provides an excellent model to investigate the direct effect of various cytokines on Ig production. Using this culture system, we examined the effect of IL-2 alone or in combination with other cytokines. IL-2 alone had only a moderate effect on Ig production by anti-CD40-activated B cells if compared with the effect of IL-10. However, IL-2 significantly augmented the synthesis of IgM, IgA, and IgG, including all IgG subclasses by anti-CD40-activated B cells cultured in the presence of IL-10. Both IgD(-) and IgD(+) B cells showed an increase of IL-10-induced Ig production if IL-2 was added to the culture. The addition of IL-2 also increased immunoglobulin synthesis by anti-CD40/IL-10-activated B cells from patients with common variable immunodeficiency (CVI) and defective IL-2 production, suggesting that in a subgroup of CVI patients the IL-2 deficiency may contribute to the observed hypogammaglobulinemia. In contrast, the addition of IL-2 had a suppressive effect on IgE and IgG(4) production by B cells cultured in the presence of anti-CD40 and IL-4. These data demonstrate that IL-2 plays an active role in the regulation of Ig production via CD40 by anti-CD40-activated B cells. (C) 1994 Academic Press, Inc.
引用
收藏
页码:373 / 379
页数:7
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