The accuracy center of a eukaryotic ribosome

被引：26

作者：

Liebman, SW

Chernoff, YO

Liu, R

机构：

[1] Department of Biological Sciences, University of Illinois at Chicago

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 1995年 / 73卷 / 11-12期

关键词：

ribosomal RNA; ribosomal protein; yeast; translational accuracy;

D O I：

10.1139/o95-123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in yeast ribosomal proteins and ribosomal RNAs have been shown to affect translational fidelity. These mutations include: proteins homologous to Escherichia coli's S4, S5, and S12; a eukaryote specific ribosomal protein; yeast ribosomal rRNA alterations at positions corresponding to 517, 912, and 1054 in 16S E. coli rRNA and to 2658 in the sarcin-ricin domain of 23S E. coli rRNA. Overall there appears to be a remarkable conservation of the accuracy center throughout evolution.

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页码：1141 / 1149

页数：9

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