SYNTHESIS OF 8- AND 9-HYDROXYBENZO[A]PYRENE AND ROLE OF PRODUCTS IN BENZO[A]PYRENE METABOLISM

被引:42
作者
SIMS, P
机构
[1] Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital
来源
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC | 1968年 / 01期
关键词
D O I
10.1039/j39680000032
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
8- and 9-Hydroxybenzo[a]pyrene have been synthesised. The absorption spectrum and chromatographic properties of the 9-isomer are identical with those of a phenol derived from a metabolite of benzo[a]pyrene in rat-liver homogenate.
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页码:32 / &
相关论文
共 8 条
[1]  
BACHMANN WE, 1941, J AM CHEM SOC, V63, P1685
[2]  
BACHMANN WE, 1941, J AM CHEM SOC, V63, P1682
[3]  
CONNEY AH, 1957, J BIOL CHEM, V228, P753
[4]   OXIDATION OF CARCINOGENIC HYDROCARBONS BY OSMIUM TETROXIDE [J].
COOK, JW ;
SCHOENTAL, R .
JOURNAL OF THE CHEMICAL SOCIETY, 1948, (FEB) :170-173
[5]  
COOK JW, 1933, J CHEM SOC, P398
[6]   THE DIRECT HYDROXYLATION OF 1'-2'-3'-4'-TETRAHYDRO-3-4-BENZPYRENE [J].
KON, GAR ;
ROE, EMF .
JOURNAL OF THE CHEMICAL SOCIETY, 1945, (MAR-) :143-146
[7]   METABOLISM OF BENZO[A]PYRENE BY RAT-LIVER HOMOGENATES [J].
SIMS, P .
BIOCHEMICAL PHARMACOLOGY, 1967, 16 (04) :613-&
[8]  
WIEGERT F, 1946, CANCER RES, V6, P97