VALPROIC ACID PHENYTOIN INTERACTION

被引：32

作者：

FRIEL, PN

LEAL, KW

WILENSKY, AJ

机构：

[1] Epilepsy Center, Department of Neurological Surgery, University of Washington School of Medicine, Seattle, WA

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 02期

关键词：

Phenytoin-Drug interaction; Protein binding; Salivary phenytoin; Valproic acid;

D O I：

10.1097/00007691-197901020-00005

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The interaction between valproic acid (VPA) and pheny-toin (DPH) was examined during therapeutic monitoring in an epileptic outpatient population. Gas-liquid chromatographic methods were used to measure DPH and VPA concentrations. (1) In 12 patients on stable DPH regimens, the mean DPH level declined from 19.7 to 15.3 Mg/ml when VPA was added (p < 0.001). (2) In 20 patients receiving DPH and VPA, the median free fraction was 15.8%, compared to 9.1% free DPH in 40 patients receiving DPH only or DPH and phenobarbital (p < 0.001). (3) Addition of VPA to a stable DPH regimen may result in a transient increased risk of DPH toxicity, followed by restabilization at the original free DPH level. © Raven Press, New York.

引用

页码：243 / 248

页数：6

共 12 条

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