EFFECT OF PROSTACYCLIN ON ANTIGEN-INDUCED IMMEDIATE BRONCHOCONSTRICTION IN ASTHMATIC-PATIENTS

被引：18

作者：

BIANCO, S

ROBUSCHI, M

GRUGNI, A

CESERANI, R

GANDOLFI, C

机构：

[1] CLIN TISIOL & MALATTIE APPARATO RESP, VIA COMMENDA 16, MILANO, ITALY

[2] RSB FARMITALIA CARLO ERBA, MILANO, ITALY

来源：

PROSTAGLANDINS AND MEDICINE | 1979年 / 3卷 / 01期

关键词：

D O I：

10.1016/0161-4630(79)90014-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of premedication with inhaled prostacyclin (PCI2) on the allergen induced immediate bronchoconstriction was investigated in 10 asthmatic patients, under single blind conditions, by means of a body plethysmograph. Statistical analysis (Dunnett's testy did not show any significant difference between PGI2 and placebo. The possible meaning of these results is discussed. © 1979.

引用

收藏

页码：39 / 45

页数：7

相关论文

共 10 条

[1] PREVENTION OF ASPECIFICALLY INDUCED BRONCHOCONSTRICTION BY PGI2 AND 20-METHYL-PGI2 IN ASTHMATIC-PATIENTS [J].

BIANCO, S ;

ROBUSCHI, M ;

CESERANI, R ;

GANDOLFI, C ;

KAMBUROFF, PL .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1978, 10 (07) :657-674

[2] A MULTIPLE COMPARISON PROCEDURE FOR COMPARING SEVERAL TREATMENTS WITH A CONTROL [J].

DUNNETT, CW .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1955, 50 (272) :1096-1121

[3]

FISH JE, 1977, AM REV RESPIR DIS, V115, P371

[4] ROLE OF VAGUS NERVES IN EXPERIMENTAL ASTHMA IN ALLERGIC DOGS [J].

GOLD, WM ;

YU, DYC ;

KESSLER, GF .

JOURNAL OF APPLIED PHYSIOLOGY, 1972, 33 (06) :719-+

[5]

HUITSON A, 1966, ANAL VARIANCE, P30

[6] IMMUNOLOGICAL RELEASE OF CHEMICAL MEDIATORS FROM HUMAN TISSUES [J].

KALINER, M ;

AUSTEN, KF .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1975, 15 :177-189

[7] ASPECTS OF BRONCHIAL REACTIVITY TO PROSTAGLANDINS AND ASPIRIN IN ASTHMATIC-PATIENTS [J].

PASARGIKLIAN, M ;

BIANCO, S ;

ALLEGRA, L ;

MOAVERO, NE ;

PETRIGNI, G ;

ROBUSCHI, M ;

GRUGNI, A .

RESPIRATION, 1977, 34 (02) :79-91

[8] BRONCHOPROVOCATION - EFFECT ON PRIMING AND DESENSITIZATION PHENOMENON IN LUNG [J].

ROSENTHAL, RR ;

NORMAN, PS ;

SUMMER, WR .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1975, 56 (05) :338-346

[9] COMPARISON OF PROTECTIVE EFFECT OF FENOTEROL AND SCH-1000 ON ALLERGEN-INDUCED ASTHMA [J].

RUFFIN, RE ;

COCKCROFT, DW ;

HARGREAVE, FE .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1978, 61 (01) :42-47

[10]

WALKER JL, 1973, ADV BIOSCI, V9, P235