RANK ORDER OF SARCOMA SUSCEPTIBILITY AMONG MOUSE STRAINS REVERSES WITH LOW CONCENTRATIONS OF CARCINOGEN

被引：25

作者：

PREHN, LM

LAWLER, EM

机构：

来源：

SCIENCE | 1979年 / 204卷 / 4390期

关键词：

D O I：

10.1126/science.432644

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ten mouse strains in which aryl hydrocarbon hydroxylase can be induced, or F1 hybrids of these strains, were ranked according to their sarcoma susceptibility when exposed to a high concentration (5 percent) of the chemical carcinogen 3-methylcholanthrene. This rank order was reversed when the concentration of 3-methylcholanthrene was reduced to 0.05 percent.

引用

页码：309 / 310

页数：2

共 7 条

[1]

BARTLETT GL, 1972, J NATL CANCER I, V49, P493

[2] EVIDENCE OF A GENETIC RELATIONSHIP BETWEEN SUSCEPTIBILITY TO 3-METHYLCHOLANTHRENE-INDUCED SUBCUTANEOUS TUMORS AND INDUCIBILITY OF ARYL HYDROCARBON HYDROXYLASE [J].