ALPHA-METHYL TRYPTOPHAN AS A TRACER FOR INVIVO STUDIES OF BRAIN-SEROTONIN SYSTEM, FROM AUTORADIOGRAPHY TO POSITRON EMISSION TOMOGRAPHY

被引：13

作者：

DIKSIC, M ^{[1
]}

机构：

[1] MCGILL UNIV, MONTREAL NEUROL INST, MONTREAL H3A 2B4, QUEBEC, CANADA

来源：

JOURNAL OF CHEMICAL NEUROANATOMY | 1992年 / 5卷 / 04期

关键词：

D O I：

10.1016/0891-0618(92)90026-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The procedure for measuring the brain serotonin synthesis rate in living brain using labelled alpha-methyl-L-tryptophan (alpha-MTrp), a tryptophan analog, is described. This tracer could also be used for the anterograde axonal transport measurement of serotonin. One advantage of this method is that alpha-MTrp is converted in situ into a serotonin tracer, alpha-methyl serotonin, and should be distributed into the same compartments as serotonin.

引用

页码：349 / 354

页数：6

共 13 条

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