POTENTIATION OF VASCULAR SMOOTH-MUSCLE CELL-ACTIVITY BY CYCLOSPORINE-A

被引：14

作者：

LOCHER, R ^{[1
]}

HUSS, R ^{[1
]}

VETTER, W ^{[1
]}

机构：

[1] UNIV HOSP ZURICH, DEPT INTERNAL MED, RAMISTR 100, CH-8091 ZURICH, SWITZERLAND

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 41卷 / 04期

关键词：

VASOCONSTRICTION; CYCLOSPORINE-A; VASCULAR SMOOTH MUSCLE CELLS; CYTOSOLIC FREE CALCIUM; CELL PROLIFERATION; PHOSPHOINOSITIDE TURNOVER; CYCLOSPORINE-A-INDUCED HYPERTENSION; PDGF; ADVERSE EFFECT;

D O I：

10.1007/BF00314955

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Pretreatment of rat vascular smooth muscle cells with cyclosporin A caused concentration- and time-dependent enhancement of both angiotensin 11- and platelet-derived growth factor-stimulated cellular functions, which may be related to a rise in vascular tone. In particular, cyclosporin A increased cytosolic free calcium, and augmented the agonist-induced formation of inositol polyphosphate. In addition, it markedly increased the sensitivity of the cells to platelet-derived growth factor-mediated stimulation of thymidine incorporation. The potentiation of vascular smooth muscle cell activity by cyclosporin A may be a novel mechanism by which it exerts an adverse vasoconstrictor effect.

引用

页码：297 / 301

页数：5

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