LITHIATION OF N-BOC-2-METHYLTETRAHYDRO-1,3-OXAZINE - A SYNTHETIC EQUIVALENT FOR 1-LITHIO-3-HYDROXY-1-PROPYLAMINE

被引：18

作者：

BEAK, P

YUM, EK

机构：

[1] Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 04期

关键词：

D O I：

10.1021/jo00056a010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A alpha-metalo amine synthetic equivalent of an unactivated primary amine, 1-lithio-3-hydroxy-1-propylamine (7) is provided by the lithiation of N-Boc-2-methyltetrahydro-1,3-oxazine (8) to give 9 which on reaction with electrophiles and hydrolysis gives derivatives of 1-substituted 3-hydroxy-1-propylamines 10-24.

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页码：823 / 824

页数：2

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