ABNORMAL PATTERN OF CEREBRAL GLUCOSE METABOLIC RATES INVOLVING LANGUAGE AREAS IN YOUNG-ADULTS WITH DOWN-SYNDROME

被引：33

作者：

AZARI, NP ^{[1
]}

HORWITZ, B ^{[1
]}

PETTIGREW, KD ^{[1
]}

GRADY, CL ^{[1
]}

HAXBY, JV ^{[1
]}

GIACOMETTI, KR ^{[1
]}

SCHAPIRO, MB ^{[1
]}

机构：

[1] NIMH, DIV APPL & SERV RES, BETHESDA, MD 20892 USA

来源：

BRAIN AND LANGUAGE | 1994年 / 46卷 / 01期

关键词：

D O I：

10.1006/brln.1994.1001

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Correlational and discriminant analyses were applied to “resting” state (eyes covered, ears plugged) regional cerebral glucose metabolic data, obtained with positron emission tomography (PET) and [18F] fluorodeoxyglucose in 14 retarded adults with Down syndrome (10 men, 4 women; age 26-38 years) and 17 age- and sex-matched controls. Down and control subjects showed no differences in the pattern of correlations. However, a discriminant function, reflecting regional interactions involving primary language areas, successfully classified the Down (100%) and control (88%) subjects. The results are consistent with a disruption of brain regional interactions involving language areas in adults with Down syndrome. © 1994 Academic Press, Inc.

引用

页码：1 / 20

页数：20

共 67 条

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