GASTRIN RECEPTOR GENE-EXPRESSION IN SEVERAL HUMAN CARCINOMAS

被引：41

作者：

MATSUSHIMA, Y

KINOSHITA, Y

NAKATA, H

INOMOTONARIBAYASHI, Y

ASAHARA, M

KAWANAMI, C

NAKAMURA, A

ITO, M

MATSUI, T

FUJIWARA, T

WATANABE, H

CHIBA, T

机构：

[1] KOBE UNIV,SCH MED,DIV GERONTOL,CHUO KU,KOBE 650,JAPAN

[2] KOBE UNIV,SCH MED,DEPT INTERNAL MED,DIV 3,CHUO KU,KOBE 650,JAPAN

[3] NIIGATA UNIV,SCH MED,DEPT PATHOL,NIIGATA 951,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1994年 / 85卷 / 08期

关键词：

GASTRIN RECEPTOR; SMALL CELL LUNG CANCER; SMALL CELL GASTRIC CANCER; GASTRIC CANCER; COLON CANCER;

D O I：

10.1111/j.1349-7006.1994.tb02953.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrin has been shown to enhance the growth of various human tumors. The present study was designed to examine the gastrin receptor gene expression in various human carcinoma cell lines and in surgically resected carcinoma tissues. By Northern blot analysis, gastrin receptor mRNA was detected in 3 out of 7 small cell lung carcinoma cell lines. Gastrin receptor mRNA was also expressed in one out of 8 colon carcinoma cell lines and 2 out of 10 colon carcinoma tissues. Moreover, one of two small cell carcinoma cell lines of the stomach clearly expressed gastrin receptor mRNA. However, none of the gastric adenocarcinoma cell lines or surgically resected gastric adenocarcinomas tested had any detectable expression of gastrin receptor gene. These findings may suggest a role of gastrin receptor in the growth and differentiation of certain human carcinomas.

引用

页码：819 / 824

页数：6

共 36 条

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