INSECTICIDAL AND CYTOTOXIC EFFECTS OF NATURAL AND HEMISYNTHETIC DESTRUXINS

被引：49

作者：

DUMAS, C

ROBERT, P

PAIS, M

VEY, A

QUIOT, JM

机构：

[1] CNRS,INRA,RECH PATHOL COMPAREE STN,F-30380 ST CHRISTOL ALES,FRANCE

[2] INRA,RECH LUTTE BIOL STN,F-78285 GUYANCOURT,FRANCE

[3] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1994年 / 108卷 / 02期

关键词：

DESTRUXINS; FUNGAL INFECTION; METARHIZIUM ANISOPLIAE;

D O I：

10.1016/1367-8280(94)90031-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The insecticidal and cytotoxic effects of 13 natural and hemisynthetic destruxins have been studied. DE shows insecticidal effects similar to those of DA, while DE and DA are more active than all the other natural compounds and analogues tested. Brominated destruxin is a relatively active analogue displaying particular modalities of cytotoxic effects which reflect a certain originality of its mode of action. The linear molecule resulting from the opening of the DA cycle is not toxic. The most hydrophilic destruxins showing e.g. charged radicals (COO-) appear the least toxic probably because they do not penetrate easily the cellular membranes.

引用

页码：195 / 203

页数：9

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