THE NA+/K+ PUMP - STRUCTURE AND FUNCTION OF THE ALPHA-SUBUNIT

被引：23

作者：

VASILETS, LA

SCHWARZ, W

机构：

[1] MAX PLANCK INST BIOPHYS, KENNEDY ALLEE 70, D-60596 FRANKFURT, GERMANY

[2] RUSSIAN ACAD SCI, INST CHEM PHYS, CHERNOGOLOVKA, RUSSIA

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 1994年 / 4卷 / 3-4期

关键词：

SODIUM PUMP; ALPHA-SUBUNIT; ISOFORMS; REGULATORY PHOSPHORYLATION; BINDING SITES; CURRENT-VOLTAGE DEPENDENCE;

D O I：

10.1159/000154714

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Major, functionally relevant features of Na+/K+-ATPase are located on the alpha-subunit of the alphabeta-heterodimer. They include the binding sites for the transported cations, the binding pocket and phosporylation site for ATP as well as regulatory phosphorylation sites for protein kinases, sensitivity for cardiac glycosides and isoform specificity. These regions of the alpha-subunit are reviewed, and structure-function relationships are discussed. The discussion is based on electrophysiological data that were obtained from Xenopus oocytes with only endogenous pumps or with expressed pumps from other species or pumps that were genetically modified.

引用

收藏

页码：81 / 95

页数：15

相关论文

共 91 条

[1] BIOCHEMICAL ASPECTS OF ACTIVE TRANSPORT [J].

ALBERS, RW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1967, 36 :727-+

[2]

ANDERSEN JP, 1992, ACTA PHYSIOL SCAND, V146, P151

[3] EPITOPE MAPPING BY AMINO-ACID-SEQUENCE-SPECIFIC ANTIBODIES REVEALS THAT BOTH ENDS OF THE ALPHA-SUBUNIT OF NA+/K+-ATPASE ARE LOCATED ON THE CYTOPLASMIC SIDE OF THE MEMBRANE [J].

ANTOLOVIC, R ;

BRULLER, HJ ;

BUNK, S ;

LINDER, D ;

SCHONER, W .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 199 (01) :195-202

[4] FAST CHARGE TRANSLOCATIONS ASSOCIATED WITH PARTIAL REACTIONS OF THE NA,K-PUMP .2. MICROSCOPIC ANALYSIS OF TRANSIENT CURRENTS [J].

APELL, HJ ;

BORLINGHAUS, R ;

LAUGER, P .

JOURNAL OF MEMBRANE BIOLOGY, 1987, 97 (03) :179-191

[5] MOLECULAR-CLONING OF THE NA,K-ATPASE ALPHA-SUBUNIT IN DEVELOPING BRINE SHRIMP AND SEQUENCE COMPARISON WITH HIGHER ORGANISMS [J].

BAXTERLOWE, LA ;

JIAN, ZG ;

BERGSTROM, EE ;

HOKIN, LE .

FEBS LETTERS, 1989, 257 (01) :181-187

[6] PHOSPHORYLATION OF THE CATALYTIC SUBUNIT OF NA+,K+-ATPASE INHIBITS THE ACTIVITY OF THE ENZYME [J].

BERTORELLO, AM ;

APERIA, A ;

WALAAS, SI ;

NAIRN, AC ;

GREENGARD, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11359-11362

[7] DEPENDENCE OF NA+ PUMP CURRENT ON EXTERNAL MONOVALENT CATIONS AND MEMBRANE-POTENTIAL IN RABBIT CARDIAC PURKINJE-CELLS [J].

BIELEN, FV ;

GLITSCH, HG ;

VERDONCK, F .

JOURNAL OF PHYSIOLOGY-LONDON, 1991, 442 :169-189

[8] ADVANCES IN NA+,K+-ATPASE STUDIES - FROM PROTEIN TO GENE AND BACK TO PROTEIN [J].

BROUDE, NE ;

MODYANOV, NN ;

MONASTYRSKAYA, GS ;

SVERDLOV, ED .

FEBS LETTERS, 1989, 257 (01) :1-9

[9] FUNCTIONAL EXPRESSION OF N-TERMINAL TRUNCATED ALPHA-SUBUNITS OF NA,K-ATPASE IN XENOPUS-LAEVIS OOCYTES [J].

BURGENERKAIRUZ, P ;

HORISBERGER, JD ;

GEERING, K ;

ROSSIER, BC .

FEBS LETTERS, 1991, 290 (1-2) :83-86

[10] MUTATION OF A CYSTEINE IN THE 1ST TRANSMEMBRANE SEGMENT OF NA,K-ATPASE ALPHA SUBUNIT CONFERS OUABAIN RESISTANCE [J].

CANESSA, CM ;

HORISBERGER, JD ;

LOUVARD, D ;

ROSSIER, BC .

EMBO JOURNAL, 1992, 11 (05) :1681-1687

← 1 2 3 4 5 6 7 8 9 10 →