SYNTHESIS OF OPTICALLY-ACTIVE GLYCERIC ACID-DERIVATIVES FROM ASCORBIC ACIDS

被引：10

作者：

CARLSEN, PHJ

MISUND, K

ROE, J

机构：

[1] BORREGARD FINE CHEM,RES & DEV,N-1701 SARPSBORG,NORWAY

[2] WEIDERS FARMASOYTISKE AS,N-0133 OSLO,NORWAY

来源：

ACTA CHEMICA SCANDINAVICA | 1995年 / 49卷 / 04期

关键词：

D O I：

10.3891/acta.chem.scand.49-0297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of acetals and ketals of L-ascorbic acid and D-isoascorbic acid has been studied. A convenient and inexpensive method involving reflux in acetone in the presence of an acidic ion-exchange resin was developed. In a perruthenate-catalyzed oxidative degradation reaction using sodium hypochlorite as the stoichiometric oxidant at pH 8.0, acetals or ketals of L-ascorbic acid were converted in high yields into the corresponding acetals or ketals of (S)-glyceric acid as their sodium salts. D-Isoascorbic acid similarly gave the (R)-glyceric acid derivatives.

引用

页码：297 / 300

页数：4

共 39 条

[1] THE CHEMISTRY OF L-ASCORBIC AND D-ISOASCORBIC ACIDS .1. THE PREPARATION OF CHIRAL BUTANETRIOLS AND BUTANETETROLS [J].