EFFECT OF SEAWEED PREPARATIONS ON MURINE IMMUNOCYTES

被引：12

作者：

MIZUKOSHI, S

MATSUOKA, H

NAKAMURA, K

KATO, F

机构：

[1] Biochemistry Research Laboratory, Central Research Institute, Ishihara Sangyo Kaisha, Ltd., Shiga, 525, Kusatsu

来源：

JOURNAL OF APPLIED PHYCOLOGY | 1993年 / 5卷 / 06期

关键词：

MARINE ALGAE; IMMUNOSUPPRESSIVE ACTIVITY; MURINE IMMUNOCYTE; MITOGENIC RESPONSE; INTERLEUKIN; 1; MIXED LYMPHOCYTE REACTION;

D O I：

10.1007/BF02184642

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

During a screening programme for new medical agents, many aqueous extracts from 59 species of seaweed were found to possess bioactivity against murine immunocytes. Thirty-eight extracts (8 green, 12 brown, 18 red algae) showed suppressive effects on the mitogenic response. Furthermore, 16 extracts (2 green, 6 brown, 8 red algae) suppressed the production of Interleukin 1 (IL-1) from murine macrophage. Using the murine mixed lymphocyte reaction assay, suppressive effects were observed in 4 red algae, but none in green or brown algae. Nine seaweed extracts suppressed the production of secondary antibody (IgG, IgM). Extracts of 3 red algae suppressed strongly the proliferation of bone marrow cells, but 2 other red algae caused stimulation above 200%. This is apparently the first report showing immunosuppressive activity from marine algae.

引用

页码：629 / 637

页数：9

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