IDENTIFICATION OF A MEMBRANE-ASSOCIATED RECEPTOR FOR TRANSFORMING GROWTH-FACTOR TYPE-E

被引：12

作者：

PARNELL, PG ^{[1
]}

CARTER, BJ ^{[1
]}

HALPER, J ^{[1
]}

机构：

[1] UNIV GEORGIA, COLL VET MED, DEPT PATHOL, ATHENS, GA 30602 USA

来源：

JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH | 1995年 / 15卷 / 05期

关键词：

D O I：

10.3109/10799899509079904

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified the receptor for epithelial type transforming growth factor (TGFe). TGFe, a member of the epithelin/granulin family of proteins, is present primarily in tissues of epithelial origin. It is a powerful mitogen for epithelial and fibroblastic cells. TGFe, iodinated using an immobilized glucose oxidase-lactoperoxidase method, was chemically crosslinked to receptors on membranes isolated from SW-13 adrenal carcinoma cells by the crosslinker disuccinimidyl suberate (DSS). The receptor appears to be a protein which migrates at an apparent molecular weight of approximately 170-175 kDa under reducing and nonreducing conditions in SDS-polyacrylamide gels.

引用

页码：747 / 756

页数：10

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