DESIGN OF SPECIFIC INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME - NEW CLASS OF ORALLY ACTIVE ANTIHYPERTENSIVE AGENTS

被引：1891

作者：

ONDETTI, MA ^{[1
]}

CUSHMAN, DW ^{[1
]}

机构：

[1] SQUIBB INST MED RES,PRINCETON,NJ 08540

来源：

SCIENCE | 1977年 / 196卷 / 4288期

关键词：

D O I：

10.1126/science.191908

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：441 / 444

页数：4

共 22 条

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[2] REVERSIBLE INHIBITION OF CARBOXYPEPTIDASE A .2. INHIBITION OF ESTERASE-ACTIVITY BY DICARBOXYLIC-ACID ANIONS [J].

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[4] INHIBITION O HOMOGENEOUS ANGIOTENSIN-CONVERTING ENZYME OF RABBIT LUNG BY SYNTHETIC VENOM PEPTIDES OF BOTHROPS-JARARACA [J].

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CUSHMAN, DW .

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[5]

Cushman D, 1972, HYPERTENSION 1972, P532

[6] INHIBITION OF ANGIOTENSIN-CONVERTING ENZYME BY ANALOGS OF PEPTIDES FROM BOTHROPS-JARARACA VENOM [J].

CUSHMAN, DW ;

PLUSCEC, J ;

WILLIAMS, NJ ;

WEAVER, ER ;

SABO, EF ;

KOCY, O ;

CHEUNG, HS ;

ONDETTI, MA .

EXPERIENTIA, 1973, 29 (08) :1032-1035

[7] SPECTROPHOTOMETRIC ASSAY AND PROPERTIES OF ANGIOTENSIN-CONVERTING ENZYME OF RABBIT LUNG [J].

CUSHMAN, DW ;

CHEUNG, HS .

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[8]

DAS M, 1975, J BIOL CHEM, V250, P6762

[9]

DOUGLAS JR, 1976, J PHARMACOL EXP THER, V196, P35

[10] CARBOXYCATHEPSIN - KEY REGULATORY COMPONENT OF 2 PHYSIOLOGICAL SYSTEMS INVOLVED IN REGULATION OF BLOOD PRESSURE [J].

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PAVLIKHINA, LV ;

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