STUDIES ON SIOMYCIN .2. COMPOSITION AND DEGRADATION PRODUCTS OF SIOMYCIN A

From the hydrolysate of siomycin A, an antibiotic from Streptomyces sioyaensis, L-threonine, L-alanine, L-valine, D-cysteine and three thiazole-4-carboxylic acid derivatives were isolated. These thiazoles were identified as thiostreptine, 2-aminomethylthiazole-4-carboxylic acid and 2-(l-amino acetonyl) thiazole-4 carboxylic acid. A 4-(α-hydroxyethyl)-8-hydroxyquinaldic acid, and two unidentified C10- and C12-compounds were also isolated in the hydrolysate. The formation of pyruvic acid (2 moles), α-amino-w-butyric acid (less than 1 mole), propionic acid (2∼3 moles) and acetaldehyde (1 mole) by the action of acid or alkali on siomycin A was demonstrated. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.