5-IMINODAUNORUBICIN - REDUCED CARDIOTOXIC PROPERTIES IN AN ANTI-TUMOR ANTHRACYCLINE

被引：131

作者：

TONG, GL ^{[1
]}

HENRY, DW ^{[1
]}

ACTON, EM ^{[1
]}

机构：

[1] SRI INT,DEPT BIO ORGAN CHEM,MENLO PK,CA 94025

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 01期

关键词：

D O I：

10.1021/jm00187a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the first quinone-modified analogue of either daunorubicin or adriamycin. This product retains antileukemic activity in mice, is less cardiotoxic by electrocardiographic measurements in rats, and is nonmutagenic in Salmonella typhimurium (Ames test). © 1979, American Chemical Society. All rights reserved.

引用

页码：36 / 39

页数：4

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