DEXAMETHASONE INCREASES NEUTRAL SPHINGOMYELINASE ACTIVITY AND SPHINGOSINE LEVELS IN 3T3-L1 FIBROBLASTS

被引：44

作者：

RAMACHANDRAN, CK ^{[1
]}

MURRAY, DK ^{[1
]}

NELSON, DH ^{[1
]}

机构：

[1] UNIV UTAH,SCH MED,DEPT PHYSIOL,SALT LAKE CITY,UT 84132

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)92068-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of neutral sphingomyelinase (EC 3.1.4.12) in a plasma membrane enriched fraction was found to be increased in dexamethasone treated cells. The elevation of sphingomyelinase activity was blocked by cycloheximide indicating that protein synthesis was required for the steroid action. Ceramidase (EC3.5.1.23) activity was unaffected by the dexamethasone treatment. Levels of sphingosine in 3T3-L1 Cells were also increased after treatment with 10-7 M dexamethasone for 2 and 4 hours. © 1990.

引用

页码：607 / 613

页数：7

共 18 条

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