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ISOLATION OF A SIMIAN IMMUNODEFICIENCY VIRUS RELATED TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-2 FROM A WEST AFRICAN PET SOOTY MANGABEY

被引：105
作者：
MARX, PA
LI, Y
LERCHE, NW
SUTJIPTO, S
GETTIE, A
YEE, JA
BROTMAN, BH
PRINCE, AM
HANSON, A
WEBSTER, RG
DESROSIERS, RC
机构：
[1] UNIV CALIF DAVIS, CALIF PRIMATE RES CTR, DAVIS, CA 95616 USA
[2] HARVARD UNIV, NEW ENGLAND REG PRIMATE RES CTR, SCH MED, SOUTHBOROUGH, MA 01772 USA
[3] LIBERIAN INST BIOMED RES, ROBERTSFIELD, LIBERIA
[4] NEW YORK BLOOD CTR, LINDSLEY F KIMBALL RES INST, NEW YORK, NY 10021 USA
[5] ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38101 USA
来源：
JOURNAL OF VIROLOGY | 1991年 / 65卷 / 08期
关键词：
D O I：
10.1128/JVI.65.8.4480-4485.1991
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two of 25 healthy pet sooty mangabey (SM) monkeys (Cercocebus atys) living in West Africa were seropositive by immunoblot when surveyed for antibody to simian immunodeficiency virus of macaques (SIVmac). SIVsmLIB1 was isolated from one of the pet sooty mangabeys. Nucleotide sequence data showed that this isolate is a member of the SIVsm/human immunodeficiency virus type 2 (HIV-2)/SIVmac group of primate lentiviruses. Furthermore, sequence comparisons revealed extensive genetic diversity among SIVsm isolates similar to that observed previously in SIV isolates from naturally infected African green monkeys. These observations provide additional evidence for monkey-human cross-species transmission of SIVsm as the source of HIV-2 infection of humans.
引用
收藏
页码：4480 / 4485
页数：6
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