TESTOSTERONE AND GHRH GENE-EXPRESSION IN ADULT AND OLD RATS

被引：10

作者：

COLONNA, VD

COCCHI, D

LIMA, L

MAGGI, A

MULLER, EE

机构：

[1] UNIV MILAN, DEPT PHARMACOL, VIA VANVITELLI 32, I-20129 MILAN, ITALY

[2] UNIV MILAN, INST PHARMACOL SCI, I-20133 MILAN, ITALY

[3] UNIV SANTIAGO DE COMPOSTELA, SCH MED, DEPT PHYSIOL, SANTIAGO, SPAIN

[4] UNIV MILAN, DEPT CHEMOTHERAPY & TOXICOL, I-20129 MILAN, ITALY

来源：

PEPTIDES | 1991年 / 12卷 / 02期

关键词：

TESTOSTERONE; GROWTH HORMONE-RELEASING FACTOR; GONADECTOMY; AGING;

D O I：

10.1016/0196-9781(91)90017-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of castration and testosterone replacement on GHRH gene expression was evaluated in adult male rats. Castration for 21 days did not affect GHRH mRNA levels, and also ineffective in this context was acute or chronic administration of testosterone to castrated rats. Hypothalamic GHRH mRNA was significantly reduced in aged male rats, but restoration of plasma testosterone concentrations via implanted capsules did not modify the low levels of GHRH mRNA. All in all, these findings support the notion that in adult and aged male rats GHRH-producing structures are insensitive to androgens.

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收藏

页码：309 / 312

页数：4

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