POLYMERS TO TREAT BRAIN-TUMORS

被引：75

作者：

BREM, H ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT OPHTHALMOL & ONCOL,BALTIMORE,MD 21205

来源：

BIOMATERIALS | 1990年 / 11卷 / 09期

关键词：

biodegradation; carmustine; Drug delivery; polyanhydrides;

D O I：

10.1016/0142-9612(90)90030-T

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Brain tumours are difficult to treat by conventional methods. A biodegradable polymer, poly-[bis(p-carboxyphenoxy) propane sebacic acid] with a nitrosourea, carmustine, has been demonstrated to be biocompatible in the brains of experimental animals and to release drugs in a predictable sustained manner. Carmustine impregnated in polymers appears to be more effective than when delivered by standard methods. A Phase I clinical study has demonstrated the safety of this approach in treating brain tumours and a Phase III placebo-controlled study is currently underway. Other applications of the polymer in the treatment of brain diseases are discussed. © 1990.

引用

页码：699 / 701

页数：3

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