KIDNEY GRAFT-SURVIVAL IN RATS WITHOUT IMMUNOSUPPRESSANTS AFTER INTRATHYMIC GLOMERULAR TRANSPLANTATION

被引：155

作者：

REMUZZI, G ^{[1
]}

ROSSINI, M ^{[1
]}

IMBERTI, O ^{[1
]}

PERICO, N ^{[1
]}

机构：

[1] OSPED RIUNITI BERGAMO,DIV NEPHROL,I-24100 BERGAMO,ITALY

来源：

LANCET | 1991年 / 337卷 / 8744期

关键词：

D O I：

10.1016/0140-6736(91)91368-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT1(1)) rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2.5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT1(1)) rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.

引用

页码：750 / 752

页数：3

共 20 条

[1]

BONSNES RW, 1945, J BIOL CHEM, V158, P581

[2]

Burnet FM, 1949, PRODUCTION ANTIBODIE, P102

[3] IMMUNOSUPPRESSION IN ORGAN-TRANSPLANTATION [J].

CARPENTER, CB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (17) :1224-1226

[4] CORTICOSTEROID-MEDIATED IMMUNOREGULATION IN MAN [J].

CUPPS, TR ;

FAUCI, AS .

IMMUNOLOGICAL REVIEWS, 1982, 65 :133-155

[5] THERAPY OF ACUTE CADAVERIC RENAL-ALLOGRAFT REJECTION WITH ADJUNCTIVE ANTI-THYMOCYTE GLOBULIN [J].

FILO, RS ;

SMITH, EJ ;

LEAPMAN, SB .

TRANSPLANTATION, 1980, 30 (06) :445-449

[6] CYTOMEGALO-VIRUS AS A RISK FACTOR IN RENAL-TRANSPLANTATION [J].

FRYD, DS ;

PETERSON, PK ;

FERGUSON, RM ;

SIMMONS, RL ;

BALFOUR, HH ;

NAJARIAN, JS .

TRANSPLANTATION, 1980, 30 (06) :436-439

[7]

KAHAN BD, 1989, NEW ENGL J MED, V321, P1725

[8] T-CELL TOLERANCE BY CLONAL ELIMINATION IN THE THYMUS [J].

KAPPLER, JW ;

ROEHM, N ;

MARRACK, P .

CELL, 1987, 49 (02) :273-280

[9] SELF-TOLERANCE ELIMINATES T-CELLS SPECIFIC FOR MLS-MODIFIED PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX [J].

KAPPLER, JW ;

STAERZ, U ;

WHITE, J ;

MARRACK, PC .

NATURE, 1988, 332 (6159) :35-40

[10]

LANCE EM, 1973, ADV IMMUNOL, V17, P1

← 1 2 →