PNEUMOCYSTIS-CARINII STIMULATES INVITRO PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA BY HUMAN MACROPHAGES

被引：35

作者：

TAMBURRINI, E ^{[1
]}

DELUCA, A ^{[1
]}

VENTURA, G ^{[1
]}

MAIURO, G ^{[1
]}

SIRACUSANO, A ^{[1
]}

ORTONA, E ^{[1
]}

ANTINORI, A ^{[1
]}

机构：

[1] IST SUPER SANITA, DEPT IMMUNOL, I-00161 ROME, ITALY

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 1991年 / 180卷 / 01期

关键词：

D O I：

10.1007/BF00191696

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The ability of Pneumocystis carinii to induce tumor necrosis factor (TNF)-alpha release by monocytes/macrophages from immunocompetent humans was investigated. Monocytes and monocyte-derived macrophages from healthy individuals produced an increased amount of TNF-alpha when exposed to P. carinii cysts obtained from rats with steroid-induced pneumocystosis. The cysts induced increased TNF-alpha production in a dose-dependent manner; baseline TNF-alpha production was restored after addition of an anti-P. carinii hyperimmune serum. Kinetics experiments showed that the secretion of TNF-alpha occurs early and reachs a maximal peak after 8 h. Since TNF-alpha is directly lethal to P. carinii in vitro, it is suggested that the production of this cytokine in response to the cysts may be one of the mechanisms for the control of this parasitic infection.

引用

页码：15 / 20

页数：6

共 20 条

[1]

BATE CAW, 1988, IMMUNOLOGY, V64, P227

[2]

BLACK CM, 1989, IMMUNOLOGY, V68, P570

[3] DETECTION OF TUMOR NECROSIS FACTOR FROM LIPOPOLYSACCHARIDE-STIMULATED HUMAN MONONUCLEAR-CELLS BY ENZYME-LINKED IMMUNOSORBENT-ASSAY AND CYTO-TOXICITY BIOASSAY [J].