BASAL TRANSEPIDERMAL WATER-LOSS, SKIN THICKNESS, SKIN BLOOD-FLOW AND SKIN COLOR IN RELATION TO SODIUM-LAURYL-SULFATE-INDUCED IRRITATION IN NORMAL SKIN

被引:69
作者
AGNER, T [1 ]
机构
[1] RIGSHOSP,DEPT DERMATOL,9 BLEGDAMSVEJ,DK-2100 COPENHAGEN,DENMARK
关键词
TRANSEPIDERMAL WATER LOSS; TEWL; ULTRASOUND A-SCAN; LASER DOPPLER FLOWMETRY; SKIN COLOR MEASUREMENT; SODIUM LAURYL SULFATE; SLS; SKIN IRRITATION;
D O I
10.1111/j.1600-0536.1991.tb01798.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The influence of basal transepidermal water loss (TEWL), skin thickness, blood flow and skin colour on susceptibility to sodium-lauryl-sulphate(SLS)-induced irritant contact dermatitis was studied in 70 healthy volunteers. SLS 0.5% was applied as a patch test. For assessment of basal values and skin response to SLS, bioengineering methods were used: TEWL was measured by an evaporimeter, skin thickness by ultrasound A-scan, blood flow by laser Doppler flowmetry, and skin colour by a colorimeter, using the L*a*b* system of the Commission Internationale de l'Eclairage (CIE). By use of multiple regression analysis, it was demonstrated that basal TEWL was substantially related to skin susceptibility to SLS, high basal TEWL predicting an increased susceptibility to SLS. Also increased light reflection from the skin, indicating a 'fair' skin, was found to be associated with increased susceptibility to SLS.
引用
收藏
页码:108 / 114
页数:7
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