MONITOR PEPTIDE GENE-EXPRESSION IS INCREASED BY EXOGENOUS CCK IN THE RAT PANCREAS AND IN A RAT PANCREATIC ACINAR CELL-LINE (AR4-2J)

被引：12

作者：

TSUZUKI, S ^{[1
]}

KONDO, A ^{[1
]}

FUSHIKI, T ^{[1
]}

SUGIMOTO, E ^{[1
]}

机构：

[1] KYOTO UNIV,FAC AGR,DEPT FOOD SCI & TECHNOL,NUTR CHEM LAB,KYOTO 606,JAPAN

来源：

FEBS LETTERS | 1992年 / 307卷 / 03期

关键词：

MONITOR PEPTIDE; MESSENGER RNA LEVEL; CHOLECYSTOKININ (CCK); CCK ANTAGONIST; PANCREAS; AR4-2J;

D O I：

10.1016/0014-5793(92)80719-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monitor peptide (CCK-releasing peptide) mRNA increased on the administration of CCK in rat pancreas and the AR4-2J pancreatic cell line. Subcutaneous injection of CCK into rats at 8 h intervals increased the level of monitor peptide mRNA in the pancreas. Concomitant injection of CCK antagonist CR-1409 strongly decreased it. The monitor peptide mRNA was also increased by CCK in AR4-2J cells and was decreased by the antagonist. These findings suggest that the plasma CCK induced by prolonged intake of a high protein diet may be responsible for the adaptative increase in the monitor peptide as well as exocrine proteases in the pancreas.

引用

页码：386 / 388

页数：3

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