THE LASER-DESORPTION LASER IONIZATION MASS-SPECTRA OF SOME ANTIINFLAMMATORY DRUGS

被引：2

作者：

MILNES, J ^{[1
]}

ROGERS, K ^{[1
]}

JONES, S ^{[1
]}

GORMALLY, J ^{[1
]}

机构：

[1] UNIV SALFORD,DEPT CHEM & APPL CHEM,SALFORD M5 4WT,LANCS,ENGLAND

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES | 1994年 / 132卷 / 1-2期

关键词：

LASER DESORPTION; LASER IONIZATION; TIME OF FLIGHT; ANTIINFLAMMATORY DRUGS;

D O I：

10.1016/0168-1176(93)03921-8

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The IR laser desorption/ultraviolet laser ionization time-of-flight mass spectra are reported for the anti-inflammatory drugs indomethacin, acemetacin, ibuprofen, flurbiprofen, diflunisal and mefenamic acid. It is found that the six compounds can be readily ionized by two photon absorption at a fixed wavelength of 266 nm. Mass spectra have been obtained under conditions of high ionizing irradiance and the observed fragmentation behaviour is discussed.

引用

页码：49 / 55

页数：7

共 14 条

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