SENSORY AND AUTONOMIC INNERVATION OF THE FACET JOINT IN THE RAT LUMBAR SPINE

被引：29

作者：

AHMED, M

BJURHOLM, A

KREICBERGS, A

SCHULTZBERG, M

机构：

[1] Department of Orthopaedics, Karolinska Hospital, Stockholm

[2] Clinical Research Center, Division of Basic Research in Dementia, Karolinska Institute, Huddinge Hospital, Huddinge

来源：

SPINE | 1993年 / 18卷 / 14期

关键词：

AUTONOMIC NERVOUS SYSTEM; FACET JOINT; IMMUNOHISTOCHEMISTRY; LOW-BACK PAIN; NEUROPEPTIDES; SENSORY NERVOUS SYSTEM; SYNOVIAL MEMBRANE;

D O I：

10.1097/00007632-199310001-00032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The presence of sensory and autonomic nerves in the synovial membrane of the lumbar facet joint in rats was investigated by immunohistochemistry. Substance P and calcitonin gene-related peptide immunoreactivities, representing sensory nerves, were observed as varicose fibers in the synoviocyte layer. The fibers were predominantly nonvascular. The autonomic innervation was identified by the presence of neuropeptide Y- and tyrosine hydroxylase-positive fibers. Most of these fibers were found adjacent to or within blood vessel walls. Immunoreactivity to vasoactive intestinal polypeptide was seen in varicose nerve terminals in the synoviocyte layer, mostly unrelated to blood vessels. There is accumulating evidence of an involvement of both the sensory and sympathetic nervous systems in inflammatory joint disease. The neuropeptides now identified in lumbar facet joints may prove to play a significant role in the pathogenesis of low-back pain.

引用

页码：2121 / 2126

页数：6

共 63 条

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