PROTECTION BY ALPHA(1)-ACID GLYCOPROTEIN AGAINST TUMOR NECROSIS FACTOR-INDUCED LETHALITY

被引：125

作者：

LIBERT, C ^{[1
]}

BROUCKAERT, P ^{[1
]}

FIERS, W ^{[1
]}

机构：

[1] STATE UNIV GHENT,MOLEC BIOL LAB,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1994年 / 180卷 / 04期

关键词：

D O I：

10.1084/jem.180.4.1571

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We here report that err-acid glycoprotein, a typical acute phase protein, protects mice from lethal shock induced by tumor necrosis factor (TNF) or endotoxin. The protection is observed both in normal and in galactosamine-sensitized mice. Optimal desensitization requires at least 3 mg (alpha(1)-acid glycoprotein administered 2 h before the lethal challenge. Under these conditions, complete inhibition of all TNF-induced metabolic changes was observed: fall in body temperature, release of liver transaminases, enhanced clotting time, and mortality. The known platelet aggregation-inhibitory activity of alpha(1)-acid glycoprotein provides a possible explanation for this protective capacity.

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页码：1571 / 1575

页数：5

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