TRANSPLANTATION STUDIES OF THE ROLE OF THE KIDNEY IN LONG-TERM BLOOD-PRESSURE REDUCTION FOLLOWING BRIEF ACE-INHIBITOR TREATMENT IN YOUNG SPONTANEOUSLY HYPERTENSIVE RATS

被引：17

作者：

HARRAP, SB ^{[1
]}

WANG, BZ ^{[1
]}

MACLELLAN, DG ^{[1
]}

机构：

[1] AUSTIN HOSP, DEPT SURG, HEIDELBERG, VIC 3084, AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1994年 / 21卷 / 02期

关键词：

ANGIOTENSIN-CONVERTING ENZYME; GENETIC HYPERTENSION; KIDNEYS; MALIGNANT PHASE; TRANSPLANTATION;

D O I：

10.1111/j.1440-1681.1994.tb02480.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Brief treatment with angiotensin-converting enzyme (ACE) inhibitors in young spontaneously hypertensive rats (SHR) causes a persistent reduction in blood pressure associated with a relatively selective reduction in renal vascular resistance. 2. To study the possible role of the kidney in this long-term hypotensive effect, we transplanted kidneys from untreated SHR into SHR that had been treated with perindopril (3 mg/kg per day) between 6 and 10 weeks of age and also transplanted kidneys from perindopril-pretreated SHR into untreated SHR. After transplantation, the remaining native kidney was removed so that only donor kidneys remained.

引用

页码：129 / 131

页数：3

共 8 条

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