MODIFIED SYNTHESIS OF 1-ALPHA-HYDROXYVITAMIN-D3

被引：12

作者：

GUEST, DW ^{[1
]}

WILLIAMS, DH ^{[1
]}

机构：

[1] UNIV CAMBRIDGE, CHEM LAB, CAMBRIDGE CB2 1EW, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 07期

关键词：

D O I：

10.1039/p19790001695

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Base-catalyzed deconjugation of cholesta-1,4,6-trien-3-one to cholesta-1,5,7-trien-3-one is a key step in a reported route to 1.alpha.-hydroxyvitamin D3. A procedure for greatly improving the yield of the product, which allows its isolation via direct crystallization, is reported. This procedure, used in conjunction with a recently described method for .alpha.-epoxidation of protected .DELTA.1-3.beta.-ols, was employed in a relatively efficient synthesis of 1.alpha.-hydroxyvitamin. D3.

引用

页码：1695 / 1697

页数：3

共 7 条

[1] CONVENIENT SYNTHESIS OF 1ALPHA-HYDROXY-VITAMIN-D3 [J].