NUDE-MOUSE RESISTS HEPATIC METASTASIS OF THE ALLOGENEIC-TUMOR, COLON-26

被引:4
作者
ARISAWA, Y
KUBOTA, T
SUTO, A
KODAIRA, S
ISHIBIKI, K
ABE, O
机构
[1] The Department of Surgery, School of Medicine, Keio University, Tokyo, 160, 35 Shinanomachi, Shinjuku-ku
来源
JAPANESE JOURNAL OF SURGERY | 1990年 / 20卷 / 04期
关键词
colon-26; liver metastasis; nude mouse;
D O I
10.1007/BF02470838
中图分类号
R61 [外科手术学];
学科分类号
摘要
The ability of the host-immune defense mechanism of nude mice and their immunocompetent littermates to prevent liver metastases from the murine colon carcinoma, colon-26, was assessed. Give thousand tumor cells suspended in 0.05 ml of Hank's balanced salt solution were inoculated into the spleens of BALB/c nu/+and BALB/c nu/nu mice. On the 21st day after inoculation, all the mice were sacrificed, and the liver metastases counted and the livers weighed. All the BALB/c nu/+mice were found to have developed hepatic metastases with a mean of 10 nodules, whereas no hepatic metastases were observed in any of the 10 BALB/c nude mice. On the other hand, 4 of 6 nude mice developed hepatic metastases after treatment with anti-asialo GM1 antibody. These results indicate that the BALB/c nude mouse has an excellent host-immune defense mechanism for preventing liver metastasis, with NK cells in the liver and/or blood circulation perhaps playing an important role. © 1990 The Japan Surgical Society.
引用
收藏
页码:487 / 490
页数:4
相关论文
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