SUSCEPTIBILITIES OF 540 ANAEROBIC GRAM-NEGATIVE BACILLI TO AMOXICILLIN, AMOXICILLIN-BRL-42715, AMOXICILLIN-CLAVULANATE, TEMAFLOXACIN, AND CLINDAMYCIN

Agar dilution MIC testing of amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin against 496 beta-lactamase-producing anaerobic gram-negative rods revealed MICs for 90% of the strains tested of 256.0 (amoxicillin), 2.0 (amoxicillin-BRL 42715 and amoxicillin-clavulanate), and 4.0 (temafloxacin and clindamycin) mu-g/ml. Amoxicillin, temafloxacin, and clindamycin inhibited all 44 beta-lactamase-negative strains (MICs for 90% of the strains tested, less-than-or-equal-to 2.0-mu-g/ml). BRL 42715 will not be developed, but temafloxacin merits clinical evaluation.