DEVELOPMENTAL REGULATION OF NEURAL RESPONSE TO FGF-1 AND FGF-2 BY HEPARAN-SULFATE PROTEOGLYCAN

被引:385
作者
NURCOMBE, V [1 ]
FORD, MD [1 ]
WILDSCHUT, JA [1 ]
BARTLETT, PF [1 ]
机构
[1] ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA
关键词
D O I
10.1126/science.7682010
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Murine neural precursor cells and cell lines derived from them are stimulated by members of the heparin-binding fibroblast growth factor (FGF) family. The activity of FGF is regulated by heparan sulfate proteoglycans (HSPGs), and this interaction is an essential prerequisite for the binding of growth factor to the signal transducing receptors. Messenger RNA for FGF-2 was detectable in the neuroepithelium at embryonic day 9, and the HSPGs produced by these cells at this time preferentially bound FGF-2. However, at embryonic day 11, when messenger RNA for FGF-1 was first detectable, there was a switch in the binding specificity of the HSPG to FGF-1. Thus, a single species of HSPG undergoes a rapid, tightly controlled change in growth factor-binding specificity concomitant with the temporal expression of the FGFs.
引用
收藏
页码:103 / 106
页数:4
相关论文
共 35 条
[1]   HUMAN BASIC FIBROBLAST GROWTH-FACTOR - NUCLEOTIDE-SEQUENCE AND GENOMIC ORGANIZATION [J].
ABRAHAM, JA ;
WHANG, JL ;
TUMOLO, A ;
MERGIA, A ;
FRIEDMAN, J ;
GOSPODAROWICZ, D ;
FIDDES, JC .
EMBO JOURNAL, 1986, 5 (10) :2523-2528
[2]  
ANY AH, 1990, BIOCHEM J, V265, P461
[3]   IMMORTALIZATION OF MOUSE NEURAL PRECURSOR CELLS BY THE C-MYC ONCOGENE [J].
BARTLETT, PF ;
REID, HH ;
BAILEY, KA ;
BERNARD, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (09) :3255-3259
[4]  
BERNFIELD ME, 1992, ANN REV CELL BIOL, V8, P1
[5]   MOLECULAR-CLONING AND CHARACTERIZATION OF N-SYNDECAN, A NOVEL TRANSMEMBRANE HEPARAN-SULFATE PROTEOGLYCAN [J].
CAREY, DJ ;
EVANS, DM ;
STAHL, RC ;
ASUNDI, VK ;
CONNER, KJ ;
GARBES, P ;
CIZMECISMITH, G .
JOURNAL OF CELL BIOLOGY, 1992, 117 (01) :191-201
[6]   CHARACTERIZATION OF A HEPARAN-SULFATE PROTEOGLYCAN THAT COPURIFIES WITH THE NEURAL CELL-ADHESION MOLECULE [J].
COLE, GJ ;
BURG, M .
EXPERIMENTAL CELL RESEARCH, 1989, 182 (01) :44-60
[7]   STRUCTURAL REQUIREMENTS FOR THE STIMULATION OF NEURITE OUTGROWTH BY 2 VARIANTS OF LAMININ AND THEIR INHIBITION BY ANTIBODIES [J].
EDGAR, D ;
TIMPL, R ;
THOENEN, H .
JOURNAL OF CELL BIOLOGY, 1988, 106 (04) :1299-1306
[8]   PROMINENT EXPRESSION OF ACIDIC FIBROBLAST GROWTH-FACTOR IN MOTOR AND SENSORY NEURONS [J].
ELDE, R ;
CAO, Y ;
CINTRA, A ;
BRELJE, TC ;
PELTOHUIKKO, M ;
JUNTTILA, T ;
FUXE, K ;
PETTERSSON, RF ;
HOKFELT, T .
NEURON, 1991, 7 (03) :349-364
[9]   Genetic analysis of proteoglycan structure, function and metabolism [J].
Esko, Jeffrey D. .
CURRENT OPINION IN CELL BIOLOGY, 1991, 3 (05) :805-816
[10]   HEPARIN AND HEPARAN-SULFATE INCREASE THE RADIUS OF DIFFUSION AND ACTION OF BASIC FIBROBLAST GROWTH-FACTOR [J].
FLAUMENHAFT, R ;
MOSCATELLI, D ;
RIFKIN, DB .
JOURNAL OF CELL BIOLOGY, 1990, 111 (04) :1651-1659