DIET, SMOKING, AND ALCOHOL IN CANCER OF THE LARYNX - A CASE-CONTROL STUDY

被引:41
作者
FREUDENHEIM, JL
GRAHAM, S
BYERS, TE
MARSHALL, JR
HAUGHEY, BP
SWANSON, MK
WILKINSON, G
机构
[1] Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo
[2] Division of Nutrition, Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta
[3] School of Nursing, State University of New York at Buffalo, Buffalo
[4] Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1992年 / 17卷 / 01期
关键词
D O I
10.1080/01635589209514171
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A case-control study among white men in western New York was conducted from 1975 through 1985 to examine diet and other risk factors for laryngeal cancer. Incident pathologically confirmed cases (250) and age- and neighborhood-matched controls (250) were interviewed to determine usual diet and lifetime use of tobacco and alcohol. Cigarettes were strongly associated with risk; pipes and cigars were not. Beer and hard liquor but not wine were associated with increased risk. Dietary fat and carotenoids were related to risk in opposite ways. The upper quartile odds ratio for dietary fat was 2.40 [95% confidence interval 1.26,4.55], and the upper quartile odds ratio for carotenoids was 0.51 (0.26,1.01). There was effect modification by smoking. Carotenoids were most negatively associated with risk among the lightest smokers, whereas dietary fat was most positively associated with risk among the heaviest smokers. Total calories, protein, and retinol were associated with increased risk; there was no relationship between laryngeal cancer and vitamin C, vitamin E, carbohydrate, or dietary fiber. This study again demonstrates the strong association between tobacco and alcohol and laryngeal cancer and also suggests that diets low in carotenoids and high in fat may increase risk.
引用
收藏
页码:33 / 45
页数:13
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