POU-domain proteins: structure and function developmental regulators

被引：231

作者：

Wegner, Michael ^{[1
]}

Drolet, Daniel W. ^{[1
]}

Rosenfeld, Michael G. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Howard Hughes Med Inst, Eukaryot Regulatory Biol Program, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 03期

关键词：

D O I：

10.1016/0955-0674(93)90015-I

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

POU-domain proteins are a group of developmental regulators found in organisms as distant as worm and man. The sequence conservation of the POU-domain has allowed the characterization of increasing numbers of proteins containing the domain, many of which act to control the generation and maintenance of differentiated cell phenotypes in organs as diverse as skin and brain. Analysis of the means by which POU-domain proteins regulate transcription has led to a further understanding of how this group initiates specific developmental programs.

引用

页码：488 / 498

页数：11

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