PHYSICOCHEMICAL CELL-DAMAGE IN RELATION TO LETHAL AMPHOTERICIN-B ACTION

被引：46

作者：

BEGGS, WH

机构：

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 02期

关键词：

D O I：

10.1128/AAC.38.2.363

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A direct relationship between the concentration-dependent rate of amphotericin B-induced K+ release from Candida albicans and the concentration-dependent rate of killing by the drug was established. This relationship together with the observed rapidity of both release and killing action supports the conclusion that the lethal action of amphotericin B is primarily physicochemical in nature.

引用

收藏

页码：363 / 364

页数：2

相关论文

共 10 条

[1]

BEGGS WH, 1992, RES COMMUN CHEM PATH, V77, P249

[2] AMPHOTERICIN-B - CURRENT UNDERSTANDING OF MECHANISMS OF ACTION [J].

BRAJTBURG, J ;

POWDERLY, WG ;

KOBAYASHI, GS ;

MEDOFF, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (02) :183-188

[3] DISSOCIATION BETWEEN ION PERMEABILITY AND LETHAL ACTION OF POLYENE ANTIBIOTICS ON CANDIDA-ALBICANS [J].

CHEN, WC ;

CHOU, DL ;

FEINGOLD, DS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 13 (06) :914-917

[4] RELEASE OF POTASSIUM-IONS FROM CANDIDA-ALBICANS IN PRESENCE OF POLYENE ANTIBIOTICS [J].

GALE, EF .

JOURNAL OF GENERAL MICROBIOLOGY, 1974, 80 (FEB) :451-465

[5] NATURE AND DEVELOPMENT OF PHENOTYPIC RESISTANCE TO AMPHOTERICIN-B IN CANDIDA-ALBICANS [J].

GALE, EF .

ADVANCES IN MICROBIAL PHYSIOLOGY, 1986, 27 :277-320

[6]

GALLIS HA, 1990, REV INFECT DIS, V12, P308

[7] MODE OF ACTION OF CLINICALLY IMPORTANT ANTIFUNGAL DRUGS [J].

KERRIDGE, D .

ADVANCES IN MICROBIAL PHYSIOLOGY, 1986, 27 :1-72

[8]

LAMYFREUND MT, 1985, J ANTIBIOT, V38, P753

[9] SYSTEMICALLY ADMINISTERED ANTIFUNGAL AGENTS - A REVIEW OF THEIR CLINICAL-PHARMACOLOGY AND THERAPEUTIC APPLICATIONS [J].

LYMAN, CA ;

WALSH, TJ .

DRUGS, 1992, 44 (01) :9-35

[10]

ODDS FC, 1988, CANDIDA CANDIDOSIS, P284