THE PREFERENTIAL DOPAMINE AUTORECEPTOR ANTAGONIST (+)-UH232 ANTAGONIZES THE POSITIVE REINFORCING EFFECTS OF COCAINE AND D-AMPHETAMINE IN THE ICSS PARADIGM

被引:23
作者
KLINGPETERSEN, T
LJUNG, E
SVENSSON, K
机构
[1] Department of Pharmacology, University of Göteborg, 413 90 Göteborg
关键词
(+)-UH232; COCAINE; D-AMPHETAMINE; ICSS PARADIGM; DA AUTORECEPTOR ANTAGONIST; GBR; 12909;
D O I
10.1016/0091-3057(94)90432-4
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The dopamine autoreceptor and D, preferring antagonist [cis-(+)-5-methoxy-1-methyl-2-(di-n-propylamino)tetralin] (+)-UH232, exerts weak stimulatory effects when tested in locomotor activity experiments using habituated animals. (+)-UH232 also blocks d-amphetamine-, cocaine-, and apomorphine-induced hyperactivity, but fails to induce catalepsy. Thus, the behavioral effects of (+)-UH232 appear to be dependent upon the baseline activity of the animal. The antagonistic properties of (+)-UH232 were studied in the intracranial self-stimulation (ICSS) technique in the rat. (+)-UH232 and haloperidol produced inhibitory effects over a wide dose range. Cocaine, GBR12909 and d-amphetamine clearly lowered ICSS thresholds, indicating stimulatory effects. (+)-UH232 antagonized the stimulatory effects of cocaine, GBR12909, and d-amphetamine, whereas haloperidol, at a dose producing an inhibition similar to (+)-UH232, was significantly weaker in antagonizing cocaine- or d-amphetamine-induced stimulation. This difference between (+)-UH232 and haloperidol with respect to stimulant-blocking ability, support the concept that the effects of (+)-UH232 are not representative of either classical DA agonists or DA antagonists.
引用
收藏
页码:345 / 351
页数:7
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